Clube Lyme et MVT

Transformation of Cystic Forms of Borrelia burgdorferi to Normal, Mobile Spirochetes

Summary: The purpose of this study was to evaluate the behaviour of Borrelia burgdorfer/ under controlled conditions. The occurrence of cystic forms of Borrelia burgdorferi in vitro was noted, and these cysts were able to be transformed to normal, mobile spirochetes. B. burgdorferi was cultivated in a commercial culture medium without serum. The spirochetes multiplied only slowly in this medium, and transformation to encysted forms was observed after I week. When these cysts were transferred to the same culture medium with rabbit serum, the encysted forms developed into regular, mobile spirochetes after 6 weeks, and their regeneration time was normal. Examination of these cysts in the transmission electron microscope revealed transverse fission inside the cysts. It is probable that similar phenomena may occur in vivo under conditions unfavourable for spirochetes. These observations may help to explain why diagnosis and treatment ofB. burgdorferi infections in humans can be difficult.

ILADS Chicago, Novembre 2018

Elément précédent

ILADS Chicago, Novembre 2018
Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis

Elément Suivant

Persisting atypical and cystic forms of Borrelia burgdo...

À propos de l'auteur