These findings suggest that an intrathecal production of anti–C. pneumoniae IgG is part of humoral polyreactivity driven by MS chronic brain inflammation. However, an intrathecal release of C. pneumoniae–specific oligoclonal IgG can occur in a subset of patients with MS progressive forms in whom a C. pneumoniae–persistent brain infection may play a pathogenetic role.
Chlamydia pneumoniae specific intrathecal oligoclonal antibody response is predominantly detected in a subset of multiple sclerosis patients with progressive forms
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